Sioux City to St. Louis: Road Trip Guide & Distance

How far is Sioux City from St. Louis?

The distance from Sioux City to St. Louis is 421.2 miles (677.8 km) as the crow flies. St. Louis is located SE of Sioux City. By car, the driving distance is approximately 505.4 miles, taking about 10h 10min. A direct flight would take roughly 1h 21min. Both are located in United States — Sioux City in Iowa and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Sioux City and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.