Hannibal to Sioux City: Road Trip Guide & Distance

How far is Hannibal from Sioux City?

The distance from Hannibal to Sioux City is 325.7 miles (524.1 km) as the crow flies. Sioux City is located NW of Hannibal. By car, the driving distance is approximately 390.8 miles, taking about 7h 52min. A direct flight would take roughly 1h 9min. Both are located in United States — Hannibal in Missouri and Sioux City in Iowa.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Hannibal and Sioux City. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.