Kirksville to Sioux City: Road Trip Guide & Distance

How far is Kirksville from Sioux City?

The distance from Kirksville to Sioux City is 254.1 miles (408.9 km) as the crow flies. Sioux City is located NW of Kirksville. By car, the driving distance is approximately 317.6 miles, taking about 6h 23min. A direct flight would take roughly 1h 1min. Both are located in United States — Kirksville in Missouri and Sioux City in Iowa.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Kirksville and Sioux City. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.