Knoxville to St. Louis: Road Trip Guide & Distance

How far is Knoxville from St. Louis?

The distance from Knoxville to St. Louis is 391.1 miles (629.4 km) as the crow flies. St. Louis is located WNW of Knoxville. By car, the driving distance is approximately 469.3 miles, taking about 9h 26min. A direct flight would take roughly 1h 17min. Both are located in United States — Knoxville in Tennessee and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Knoxville and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.