Knoxville to Owensboro: Road Trip Guide & Distance

How far is Knoxville from Owensboro?

The distance from Knoxville to Owensboro is 216.4 miles (348.3 km) as the crow flies. Owensboro is located NW of Knoxville. By car, the driving distance is approximately 270.5 miles, taking about 5h 27min. A direct flight would take roughly 56min. Both are located in United States — Knoxville in Tennessee and Owensboro in Kentucky.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Knoxville and Owensboro. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.