Henderson, Kentucky to Knoxville: Road Trip Guide & Distance

How far is Henderson, Kentucky from Knoxville?

The distance from Henderson, Kentucky to Knoxville is 240.6 miles (387.2 km) as the crow flies. Knoxville is located ESE of Henderson, Kentucky. By car, the driving distance is approximately 300.7 miles, taking about 6h 3min. A direct flight would take roughly 59min. Both are located in United States — Henderson, Kentucky in Kentucky and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Henderson, Kentucky and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.