St. Louis to Tupelo: Road Trip Guide & Distance

How far is St. Louis from Tupelo?

The distance from St. Louis to Tupelo is 313 miles (503.8 km) as the crow flies. Tupelo is located SSE of St. Louis. By car, the driving distance is approximately 375.7 miles, taking about 7h 33min. A direct flight would take roughly 1h 8min. Both are located in United States — St. Louis in Missouri and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for St. Louis and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.