Cape Girardeau to Tupelo: Road Trip Guide & Distance

How far is Cape Girardeau from Tupelo?

The distance from Cape Girardeau to Tupelo is 215.5 miles (346.8 km) as the crow flies. Tupelo is located SSE of Cape Girardeau. By car, the driving distance is approximately 269.4 miles, taking about 5h 25min. A direct flight would take roughly 56min. Both are located in United States — Cape Girardeau in Missouri and Tupelo in Mississippi.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.