O'Fallon, Missouri to Sioux City: Road Trip Guide & Distance

How far is O'Fallon, Missouri from Sioux City?

The distance from O'Fallon, Missouri to Sioux City is 392.6 miles (631.8 km) as the crow flies. Sioux City is located NW of O'Fallon, Missouri. By car, the driving distance is approximately 471.1 miles, taking about 9h 29min. A direct flight would take roughly 1h 17min. Both are located in United States — O'Fallon, Missouri in Missouri and Sioux City in Iowa.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for O'Fallon, Missouri and Sioux City. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.