Meridian to St. Louis: Road Trip Guide & Distance

How far is Meridian from St. Louis?

The distance from Meridian to St. Louis is 440.8 miles (709.4 km) as the crow flies. St. Louis is located N of Meridian. By car, the driving distance is approximately 529 miles, taking about 10h 38min. A direct flight would take roughly 1h 23min. Both are located in United States — Meridian in Mississippi and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading North for this distance usually means noticeable weather changes. Make sure to check the forecast for your destination before hitting the road.

Coordinates come from public place data for Meridian and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.