Cape Girardeau to Meridian: Road Trip Guide & Distance

How far is Cape Girardeau from Meridian?

The distance from Cape Girardeau to Meridian is 344.6 miles (554.5 km) as the crow flies. Meridian is located S of Cape Girardeau. By car, the driving distance is approximately 413.5 miles, taking about 8h 19min. A direct flight would take roughly 1h 12min. Both are located in United States — Cape Girardeau in Missouri and Meridian in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. As you head South, expect warmer temperatures. Make sure your car's AC is working well before embarking on this journey.

Coordinates come from public place data for Cape Girardeau and Meridian. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.