La Crosse to Saint Joseph: Road Trip Guide & Distance

How far is La Crosse from Saint Joseph?

The distance from La Crosse to Saint Joseph is 334.9 miles (538.9 km) as the crow flies. Saint Joseph is located SW of La Crosse. By car, the driving distance is approximately 401.8 miles, taking about 8h 5min. A direct flight would take roughly 1h 10min. Both are located in United States — La Crosse in Wisconsin and Saint Joseph in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for La Crosse and Saint Joseph. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.