Des Moines to La Crosse: Road Trip Guide & Distance

How far is Des Moines from La Crosse?

The distance from Des Moines to La Crosse is 195.1 miles (314 km) as the crow flies. La Crosse is located NE of Des Moines. By car, the driving distance is approximately 243.9 miles, taking about 4h 54min. A direct flight would take roughly 54min. Both are located in United States — Des Moines in Iowa and La Crosse in Wisconsin.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility. Given the short distance, driving or taking a train is often faster and more convenient than dealing with airport security and flight boarding times.

Coordinates come from public place data for Des Moines and La Crosse. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.