Knoxville to Lancaster, Pennsylvania: Road Trip Guide & Distance
How far is Knoxville from Lancaster, Pennsylvania?
The distance from Knoxville to Lancaster, Pennsylvania is 500.9 miles (806.2 km) as the crow flies. Lancaster, Pennsylvania is located NE of Knoxville. By car, the driving distance is approximately 601.1 miles, taking about 12h 6min. A direct flight would take roughly 1h 30min. Both are located in United States — Knoxville in Tennessee and Lancaster, Pennsylvania in Pennsylvania.
This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.
Coordinates come from public place data for Knoxville and Lancaster, Pennsylvania. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.
How to Get from Knoxville to Lancaster, Pennsylvania
Suggested Stops Between Knoxville & Lancaster, Pennsylvania
- 1426 mi
- 2428 mi
- 3429 mi
- 486 mi
- 5327 mi
Quick Facts
Did You Know?
- At walking speed (3 mph), it would take about 167 hours of non-stop walking
- By bicycle at 12 mph, the journey would take roughly 42 hours
- You could travel this distance about 49.7 times to circle the Earth's equator