Frederick to Knoxville: Road Trip Guide & Distance

How far is Frederick from Knoxville?

The distance from Frederick to Knoxville is 428.4 miles (689.4 km) as the crow flies. Knoxville is located WSW of Frederick. By car, the driving distance is approximately 514.1 miles, taking about 10h 20min. A direct flight would take roughly 1h 22min. Both are located in United States — Frederick in Maryland and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Frederick and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.