Indianapolis to Winston-Salem: Road Trip Guide & Distance

How far is Indianapolis from Winston-Salem?

The distance from Indianapolis to Winston-Salem is 409.9 miles (659.6 km) as the crow flies. Winston-Salem is located SE of Indianapolis. By car, the driving distance is approximately 515.3 miles, taking about 10h 3min. A direct flight would take roughly 1h 19min. Both are located in United States — Indianapolis in Indiana and Winston-Salem in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Indianapolis and Winston-Salem. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.