Hamilton, Ohio to Winston-Salem: Road Trip Guide & Distance

How far is Hamilton, Ohio from Winston-Salem?

The distance from Hamilton, Ohio to Winston-Salem is 328 miles (527.8 km) as the crow flies. Winston-Salem is located SE of Hamilton, Ohio. By car, the driving distance is approximately 393.6 miles, taking about 7h 55min. A direct flight would take roughly 1h 10min. Both are located in United States — Hamilton, Ohio in Ohio and Winston-Salem in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Hamilton, Ohio and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.