Hannibal to Sioux Falls: Road Trip Guide & Distance

How far is Hannibal from Sioux Falls?

The distance from Hannibal to Sioux Falls is 383.4 miles (617 km) as the crow flies. Sioux Falls is located NW of Hannibal. By car, the driving distance is approximately 460.1 miles, taking about 9h 15min. A direct flight would take roughly 1h 16min. Both are located in United States — Hannibal in Missouri and Sioux Falls in South Dakota.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Hannibal and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.