Kirksville to Sioux Falls: Road Trip Guide & Distance

How far is Kirksville from Sioux Falls?

The distance from Kirksville to Sioux Falls is 314.6 miles (506.3 km) as the crow flies. Sioux Falls is located NW of Kirksville. By car, the driving distance is approximately 377.5 miles, taking about 7h 36min. A direct flight would take roughly 1h 8min. Both are located in United States — Kirksville in Missouri and Sioux Falls in South Dakota.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Kirksville and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.