Des Moines to Sioux Falls: Road Trip Guide & Distance

How far is Des Moines from Sioux Falls?

The distance from Des Moines to Sioux Falls is 207.8 miles (334.5 km) as the crow flies. Sioux Falls is located NW of Des Moines. By car, the driving distance is approximately 259.8 miles, taking about 5h 14min. A direct flight would take roughly 55min. Both are located in United States — Des Moines in Iowa and Sioux Falls in South Dakota.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Des Moines and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.