Florence, South Carolina to Fort Pierce: Road Trip Guide & Distance

How far is Florence, South Carolina from Fort Pierce?

The distance from Florence, South Carolina to Fort Pierce is 467.5 miles (752.3 km) as the crow flies. Fort Pierce is located S of Florence, South Carolina. By car, the driving distance is approximately 561 miles, taking about 11h 17min. A direct flight would take roughly 1h 26min. Both are located in United States — Florence, South Carolina in South Carolina and Fort Pierce in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. As you head South, expect warmer temperatures. Make sure your car's AC is working well before embarking on this journey.

Coordinates come from public place data for Florence, South Carolina and Fort Pierce. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.