Charleston, South Carolina to Louisville: Road Trip Guide & Distance

How far is Charleston, South Carolina from Louisville?

The distance from Charleston, South Carolina to Louisville is 500.3 miles (805.2 km) as the crow flies. Louisville is located NW of Charleston, South Carolina. By car, the driving distance is approximately 596.7 miles, taking about 11h 33min. A direct flight would take roughly 1h 30min. Both are located in United States — Charleston, South Carolina in South Carolina and Louisville in Kentucky.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Charleston, South Carolina and Louisville. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.