Charleston, South Carolina to Knoxville: Road Trip Guide & Distance

How far is Charleston, South Carolina from Knoxville?

The distance from Charleston, South Carolina to Knoxville is 316.5 miles (509.3 km) as the crow flies. Knoxville is located NW of Charleston, South Carolina. By car, the driving distance is approximately 379.8 miles, taking about 7h 38min. A direct flight would take roughly 1h 8min. Both are located in United States — Charleston, South Carolina in South Carolina and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Charleston, South Carolina and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.