Anderson, South Carolina to Knoxville: Road Trip Guide & Distance

How far is Anderson, South Carolina from Knoxville?

The distance from Anderson, South Carolina to Knoxville is 123.6 miles (198.9 km) as the crow flies. Knoxville is located NW of Anderson, South Carolina. By car, the driving distance is approximately 154.5 miles, taking about 3h 6min. A direct flight would take roughly 45min. Both are located in United States — Anderson, South Carolina in South Carolina and Knoxville in Tennessee.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare. Given the short distance, driving or taking a train is often faster and more convenient than dealing with airport security and flight boarding times.

Coordinates come from public place data for Anderson, South Carolina and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.