O'Fallon, Missouri to Tupelo: Road Trip Guide & Distance

How far is O'Fallon, Missouri from Tupelo?

The distance from O'Fallon, Missouri to Tupelo is 333.4 miles (536.6 km) as the crow flies. Tupelo is located SSE of O'Fallon, Missouri. By car, the driving distance is approximately 400.1 miles, taking about 8h 3min. A direct flight would take roughly 1h 10min. Both are located in United States — O'Fallon, Missouri in Missouri and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for O'Fallon, Missouri and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.