O'Fallon, Missouri to Smyrna: Road Trip Guide & Distance

How far is O'Fallon, Missouri from Smyrna?

The distance from O'Fallon, Missouri to Smyrna is 301.4 miles (485 km) as the crow flies. Smyrna is located SE of O'Fallon, Missouri. By car, the driving distance is approximately 376.7 miles, taking about 7h 35min. A direct flight would take roughly 1h 6min. Both are located in United States — O'Fallon, Missouri in Missouri and Smyrna in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for O'Fallon, Missouri and Smyrna. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.