Clarksville to O'Fallon, Missouri: Road Trip Guide & Distance

How far is Clarksville from O'Fallon, Missouri?

The distance from Clarksville to O'Fallon, Missouri is 241.2 miles (388.2 km) as the crow flies. O'Fallon, Missouri is located NW of Clarksville. By car, the driving distance is approximately 301.6 miles, taking about 6h 4min. A direct flight would take roughly 59min. Both are located in United States — Clarksville in Tennessee and O'Fallon, Missouri in Missouri.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Clarksville and O'Fallon, Missouri. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.