Odessa to Winston-Salem: Road Trip Guide & Distance

How far is Odessa from Winston-Salem?

The distance from Odessa to Winston-Salem is 1298.2 miles (2089.2 km) as the crow flies. Winston-Salem is located ENE of Odessa. By car, the driving distance is approximately 1557.8 miles, taking about 31h 20min. A direct flight would take roughly 3h 7min. Both are located in United States — Odessa in Texas and Winston-Salem in North Carolina.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility. For a trip of this distance, flying is significantly faster. However, driving offers the flexibility to explore stops along the way.

Coordinates come from public place data for Odessa and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.