Knoxville to Winston-Salem: Road Trip Guide & Distance

How far is Knoxville from Winston-Salem?

The distance from Knoxville to Winston-Salem is 205.6 miles (330.9 km) as the crow flies. Winston-Salem is located E of Knoxville. By car, the driving distance is approximately 257 miles, taking about 5h 10min. A direct flight would take roughly 55min. Both are located in United States — Knoxville in Tennessee and Winston-Salem in North Carolina.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Knoxville and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.