Nacogdoches to Tupelo: Road Trip Guide & Distance

How far is Nacogdoches from Tupelo?

The distance from Nacogdoches to Tupelo is 390.7 miles (628.8 km) as the crow flies. Tupelo is located ENE of Nacogdoches. By car, the driving distance is approximately 468.9 miles, taking about 9h 26min. A direct flight would take roughly 1h 17min. Both are located in United States — Nacogdoches in Texas and Tupelo in Mississippi.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Nacogdoches and Tupelo. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.