Myrtle Beach to Port Saint Lucie: Road Trip Guide & Distance

How far is Myrtle Beach from Port Saint Lucie?

The distance from Myrtle Beach to Port Saint Lucie is 450.4 miles (724.8 km) as the crow flies. Port Saint Lucie is located SSW of Myrtle Beach. By car, the driving distance is approximately 540.5 miles, taking about 10h 52min. A direct flight would take roughly 1h 24min. Both are located in United States — Myrtle Beach in South Carolina and Port Saint Lucie in Florida.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Myrtle Beach and Port Saint Lucie. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.