Madison, Alabama to St. Louis: Road Trip Guide & Distance

How far is Madison, Alabama from St. Louis?

The distance from Madison, Alabama to St. Louis is 331.9 miles (534.2 km) as the crow flies. St. Louis is located NW of Madison, Alabama. By car, the driving distance is approximately 398.3 miles, taking about 8h 1min. A direct flight would take roughly 1h 10min. Both are located in United States — Madison, Alabama in Alabama and St. Louis in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Madison, Alabama and St. Louis. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.