Cape Girardeau to Madison, Alabama: Road Trip Guide & Distance

How far is Cape Girardeau from Madison, Alabama?

The distance from Cape Girardeau to Madison, Alabama is 237.5 miles (382.2 km) as the crow flies. Madison, Alabama is located SE of Cape Girardeau. By car, the driving distance is approximately 296.9 miles, taking about 5h 58min. A direct flight would take roughly 59min. Both are located in United States — Cape Girardeau in Missouri and Madison, Alabama in Alabama.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Cape Girardeau and Madison, Alabama. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.