Louisville to Winston-Salem: Road Trip Guide & Distance

How far is Louisville from Winston-Salem?

The distance from Louisville to Winston-Salem is 338 miles (543.9 km) as the crow flies. Winston-Salem is located ESE of Louisville. By car, the driving distance is approximately 434.3 miles, taking about 8h 33min. A direct flight would take roughly 1h 11min. Both are located in United States — Louisville in Kentucky and Winston-Salem in North Carolina.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Louisville and Winston-Salem. The driving distance uses an OSRM road-route result when route data is available. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.