Lancaster, Ohio to Winston-Salem: Road Trip Guide & Distance

How far is Lancaster, Ohio from Winston-Salem?

The distance from Lancaster, Ohio to Winston-Salem is 280.7 miles (451.8 km) as the crow flies. Winston-Salem is located SSE of Lancaster, Ohio. By car, the driving distance is approximately 351 miles, taking about 7h 4min. A direct flight would take roughly 1h 4min. Both are located in United States — Lancaster, Ohio in Ohio and Winston-Salem in North Carolina.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Lancaster, Ohio and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.