Chillicothe to Winston-Salem: Road Trip Guide & Distance

How far is Chillicothe from Winston-Salem?

The distance from Chillicothe to Winston-Salem is 268.9 miles (432.7 km) as the crow flies. Winston-Salem is located SE of Chillicothe. By car, the driving distance is approximately 336.1 miles, taking about 6h 46min. A direct flight would take roughly 1h 2min. Both are located in United States — Chillicothe in Ohio and Winston-Salem in North Carolina.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Chillicothe and Winston-Salem. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.