Lafayette, Indiana to Sioux Falls: Road Trip Guide & Distance

How far is Lafayette, Indiana from Sioux Falls?

The distance from Lafayette, Indiana to Sioux Falls is 549.8 miles (884.8 km) as the crow flies. Sioux Falls is located WNW of Lafayette, Indiana. By car, the driving distance is approximately 659.8 miles, taking about 13h 16min. A direct flight would take roughly 1h 36min. Both are located in United States — Lafayette, Indiana in Indiana and Sioux Falls in South Dakota.

This is a serious multi-day road trip! We strongly recommend breaking this journey up with an overnight stay to ensure you arrive safely and refreshed. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Lafayette, Indiana and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.