Iowa City to Sioux Falls: Road Trip Guide & Distance

How far is Iowa City from Sioux Falls?

The distance from Iowa City to Sioux Falls is 294.5 miles (474 km) as the crow flies. Sioux Falls is located WNW of Iowa City. By car, the driving distance is approximately 368.2 miles, taking about 7h 24min. A direct flight would take roughly 1h 6min. Both are located in United States — Iowa City in Iowa and Sioux Falls in South Dakota.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Iowa City and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.