Muscatine to Sioux Falls: Road Trip Guide & Distance

How far is Muscatine from Sioux Falls?

The distance from Muscatine to Sioux Falls is 324.5 miles (522.2 km) as the crow flies. Sioux Falls is located WNW of Muscatine. By car, the driving distance is approximately 389.4 miles, taking about 7h 50min. A direct flight would take roughly 1h 9min. Both are located in United States — Muscatine in Iowa and Sioux Falls in South Dakota.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Muscatine and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.