La Crosse to Mitchell: Road Trip Guide & Distance

How far is La Crosse from Mitchell?

The distance from La Crosse to Mitchell is 338.8 miles (545.3 km) as the crow flies. Mitchell is located W of La Crosse. By car, the driving distance is approximately 406.6 miles, taking about 8h 11min. A direct flight would take roughly 1h 11min. Both are located in United States — La Crosse in Wisconsin and Mitchell in South Dakota.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for La Crosse and Mitchell. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.