La Crosse to Sioux Falls: Road Trip Guide & Distance

How far is La Crosse from Sioux Falls?

The distance from La Crosse to Sioux Falls is 274.8 miles (442.3 km) as the crow flies. Sioux Falls is located W of La Crosse. By car, the driving distance is approximately 343.6 miles, taking about 6h 55min. A direct flight would take roughly 1h 3min. Both are located in United States — La Crosse in Wisconsin and Sioux Falls in South Dakota.

For a drive of this length, it's recommended to plan at least one quick rest stop to stretch your legs and grab a coffee. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for La Crosse and Sioux Falls. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.