La Crosse to Manhattan: Road Trip Guide & Distance

How far is La Crosse from Manhattan?

The distance from La Crosse to Manhattan is 421.7 miles (678.6 km) as the crow flies. Manhattan is located SW of La Crosse. By car, the driving distance is approximately 506 miles, taking about 10h 11min. A direct flight would take roughly 1h 21min. Both are located in United States — La Crosse in Wisconsin and Manhattan in Kansas.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for La Crosse and Manhattan. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.