Knoxville to Sikeston: Road Trip Guide & Distance

How far is Knoxville from Sikeston?

The distance from Knoxville to Sikeston is 321.3 miles (517.1 km) as the crow flies. Sikeston is located WNW of Knoxville. By car, the driving distance is approximately 385.6 miles, taking about 7h 45min. A direct flight would take roughly 1h 9min. Both are located in United States — Knoxville in Tennessee and Sikeston in Missouri.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Knoxville and Sikeston. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.