Knoxville to Pittsburgh: Road Trip Guide & Distance

How far is Knoxville from Pittsburgh?

The distance from Knoxville to Pittsburgh is 375.7 miles (604.6 km) as the crow flies. Pittsburgh is located NNE of Knoxville. By car, the driving distance is approximately 450.8 miles, taking about 9h 4min. A direct flight would take roughly 1h 15min. Both are located in United States — Knoxville in Tennessee and Pittsburgh in Pennsylvania.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Knoxville and Pittsburgh. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.