Knoxville to Murrysville: Road Trip Guide & Distance

How far is Knoxville from Murrysville?

The distance from Knoxville to Murrysville is 384.4 miles (618.7 km) as the crow flies. Murrysville is located NE of Knoxville. By car, the driving distance is approximately 461.3 miles, taking about 9h 17min. A direct flight would take roughly 1h 16min. Both are located in United States — Knoxville in Tennessee and Murrysville in Pennsylvania.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Knoxville and Murrysville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.