Knoxville to Lafayette, Indiana: Road Trip Guide & Distance

How far is Knoxville from Lafayette, Indiana?

The distance from Knoxville to Lafayette, Indiana is 347.2 miles (558.7 km) as the crow flies. Lafayette, Indiana is located NNW of Knoxville. By car, the driving distance is approximately 416.6 miles, taking about 8h 23min. A direct flight would take roughly 1h 12min. Both are located in United States — Knoxville in Tennessee and Lafayette, Indiana in Indiana.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Knoxville and Lafayette, Indiana. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.