Jefferson City to Knoxville: Road Trip Guide & Distance

How far is Jefferson City from Knoxville?

The distance from Jefferson City to Knoxville is 488.2 miles (785.7 km) as the crow flies. Knoxville is located ESE of Jefferson City. By car, the driving distance is approximately 585.8 miles, taking about 11h 47min. A direct flight would take roughly 1h 29min. Both are located in United States — Jefferson City in Missouri and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Jefferson City and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.