Hattiesburg to Knoxville: Road Trip Guide & Distance

How far is Hattiesburg from Knoxville?

The distance from Hattiesburg to Knoxville is 444.7 miles (715.6 km) as the crow flies. Knoxville is located NE of Hattiesburg. By car, the driving distance is approximately 533.6 miles, taking about 10h 44min. A direct flight would take roughly 1h 24min. Both are located in United States — Hattiesburg in Mississippi and Knoxville in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Hattiesburg and Knoxville. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.