Great Smoky Mountains to Lancaster, Pennsylvania: Road Trip Guide & Distance

How far is Great Smoky Mountains from Lancaster, Pennsylvania?

The distance from Great Smoky Mountains to Lancaster, Pennsylvania is 497 miles (799.8 km) as the crow flies. Lancaster, Pennsylvania is located NE of Great Smoky Mountains. By car, the driving distance is approximately 596.4 miles, taking about 12h 0min. A direct flight would take roughly 1h 30min. Both are located in United States — Great Smoky Mountains in Tennessee and Lancaster, Pennsylvania in Pennsylvania.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Heading East means you'll be driving into the sunrise if you start early. Keep your windshield clean for the best visibility.

Coordinates come from public place data for Great Smoky Mountains and Lancaster, Pennsylvania. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.