Frederick to Great Smoky Mountains: Road Trip Guide & Distance

How far is Frederick from Great Smoky Mountains?

The distance from Frederick to Great Smoky Mountains is 424.1 miles (682.5 km) as the crow flies. Great Smoky Mountains is located SW of Frederick. By car, the driving distance is approximately 508.9 miles, taking about 10h 14min. A direct flight would take roughly 1h 21min. Both are located in United States — Frederick in Maryland and Great Smoky Mountains in Tennessee.

This is a solid day of driving. Be sure to take breaks every 2-3 hours to avoid driver fatigue, and plan your meals ahead of time. Since you'll be heading mostly West, pack a good pair of sunglasses if you plan to drive during the late afternoon to avoid the harsh sun glare.

Coordinates come from public place data for Frederick and Great Smoky Mountains. The driving distance is estimated from straight-line distance with a road-factor model, so confirm the route in your navigation app. Fuel, flight, bus, and train values are planning estimates and can change by date, provider, road closures, and border rules.